the common genetic variant of insig2 gene rs7566605 polymorphism is associated with severe obesity in north india
نویسندگان
چکیده
background: obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. the aim of this study was to examine the association of insig2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in north indian subjects. methods: the variants were investigated for association in 642 obese and non-obese individuals. the genotyping of insig2 (rs7566605) single nucleotide polymorphism was analyzed by the taqman allelic discrimination protocol. results: a significant association was observed for insig2 (rs7566605) single nucleotide polymorphism with obesity and obesity-related phenotypes. furthermore, a significant relationship was found between the rs7566605 and insulin, homeostasis model of assessment-insulin resistance, the percentage of body fat, fat mass, leptin, and adiponectin. conclusion: the present study observed significant association between insig2 (rs7566605) single nucleotide polymorphism and obesity, as well as obesity-associated phenotypes in north indian population.
منابع مشابه
Common Genetic Variant of insig2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
Background: Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. Methods: The variants were investig...
متن کاملCommon Genetic Variant of INSIG2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
Background Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. Methods The variants were investigated ...
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A genome-wide association study showed that the tagging single nucleotide polymorphism (SNP) rs7566605 in the insulin-induced gene 2 (INSIG2) was associated with obesity. Attempts to replicate this result in different populations have produced inconsistent findings. We aimed to study the association between the rs7566605 SNP with obesity and other metabolic parameters in Malaysian Malays. Anthr...
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عنوان ژورنال:
iranian biomedical journalجلد ۲۱، شماره ۴، صفحات ۲۶۱-۲۶۹
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